tirzepatide lean mass loss

Tirzepatide linked to more lean mass loss than semaglutide — Photo by Joshua Brown on Pexels

Semaglutide vs Tirzepatide: Which Weight‑Loss Drug Spares Muscle Mass?

Semaglutide preserves lean muscle better than tirzepatide during weight-loss therapy, with trials reporting under 5% lean-mass loss versus about 7% loss for tirzepatide. As prescription GLP-1 agonists become mainstream, clinicians must weigh total weight reduction against the quality of that loss. Medical Disclaimer: This article is for informational purposes only